• Cheminformatics Scientist

    Location US-DE-Newark
    Job ID
    2018-8576
    # Positions
    1
    Exp. (Yrs)
    5+
    Category
    Research & Development
    Type
    Full Time
    Visa Sponsorship
    Yes
    Domestic Travel Required
    No
    Int'l Travel required
    No
    Company Vehicle
    No
    Working from Home Office
    No
    Relocation Eligible
    Yes
  • Company Overview

    FMC Corporation is a leading specialty company focused on agricultural and lithium technologies. We are proud that our products help grow the world's food, improve health and contribute to a more sustainable energy supply.

     

    FMC is a globally diverse organization that offers its employees exciting opportunities to work on challenging projects that are important to the achievement of our strategic objectives. Your education and professional experience are valued and put to use from day one. Your success at completing key initiatives can result in a varied, progressive and fulfilling career with FMC.

     

    With a corporate culture of innovation, integrity, responsibility and customer intimacy, we foster “The Right Chemistry” in everything we do. We are looking for people to join us in creating, developing, and improving our products, our processes, and our markets.  If you are ready to make a difference every day, FMC is ready to talk to you.

    Overview

    FMC Global Regulatory Sciences is looking for a highly-motivated individual to work in our Environmental Sciences and Risk Assessment Group in our Newark, Delaware, research facility. The Cheminformatics Scientist position requires a broad knowledge of chemistry/biochemistry (i.e. organic chemistry, biochemistry, pharmacology or similar) with practical experience of pharmacokinetics, pharmacodynamics, toxicology, metabolism and quantitative structure-activity relationships. This is an office-based position that utilizes experimental knowledge and regulatory know-how to support and advise internal multidisciplinary functions from early research and development through commercialization and defense of materials in the FMC agrochemical portfolio. This position will support internal scientists from aligned disciplines, such as toxicology, metabolism chemistry, residue analytical chemistry, and risk assessment to make informed decisions about overall risk and ability to register active ingredients and pesticide products.

    Responsibilities

    Responsibility highlights include but are not limited to the following:

    • Facilitate the use of computer models and predictive technology to determine quantitative structure-activity relationships (QSAR), complete chemical evaluations, and predict hazard for untested chemicals (impurities and degradation products of active ingredients) in support of registration approvals
    • Partner with key internal scientists, registrations managers, or external technical experts worldwide to generate necessary data for developing QSAR models for active ingredient, metabolites, impurities, and degradation products.  
    • Employ QSAR models to efficiently utilizing appropriate software to generate summary reports to meet submission deadlines.
    • Review draft reports and provide comments to CROs that generate input data for the QSAR models in order to achieve accurate, GLP-compliant studies and final reports.
    • Prepare dossier submissions in the area of toxicology/human health assessment in an appropriate format consistent with regulatory requirements according to agreed timeframes.
    • Respond appropriately to regulatory questions and requirements in the area of human health risk and ecological risk assessments to support development, registration, re-registration, and label expansion for FMC products and innovative chemistry or technology.
    • Effectively manage numerous tasks/projects simultaneously.
    • Participate in industry task forces and/or Agency meetings to keep abreast of new developments in the area of QSAR.
    • Attend professional meetings and scientific/technical training or workshops to maintain and improve technical skills.      
    • Publish or present scientific information at meetings and in journals.

    Required Education

    A Ph.D. degree in Computational Chemistry, Organic Chemistry, Biochemistry, Pharmacology or equivalent discipline with minimum 5 years of relevant experience in agricultural chemical or pharmaceutical industry; Master’s degree in Organic Chemistry, Biochemistry, or equivalent discipline with minimum 10 years of relevant experience in agricultural chemical or pharmaceutical industry.

    Qualifications

    • Familiarity with data mining / management as well as structure-based, machine learning, cheminformatics, and statistical approaches to assess toxicity.
    • Prior experience with DEREK, METEOR, MASCASE, TOPCA, OECD Toolbox, or similar computer program and database(s) to conduct QSAR evaluations and predict hazards for untested impurities and degradation products of active ingredients in support of technical equivalence.
    • Broad scientific knowledge in organic chemistry, natural products, biochemistry, pharmacology or similar chemistry discipline for agricultural or pharmaceutical products.      
    • Computer skills with data management experience with the ability to quickly learn and evaluate new software and modify or trouble-shoot existing QSAR tools.
    • Ability to critically evaluate complex scientific data in order to provide recommendations to key staff and management.
    • Strong interpersonal skills working effectively within a team environment -exchanging ideas with colleagues, sharing workload, and interacting with supervisors. Must be able to thrive in a global, customer service-oriented team with a high level of self-direction and motivation.      
    • Excellent and effective written and verbal communication skills. Technical writing for comprehensive scientific reports, hazard evaluations, and presenting chemistry to/for appropriate target audiences.
    • Strong commitment to and awareness of safety practices.  
    •  

      Additional Beneficial Experience 

    • Familiarity with chemical metabolism, pharmacology and biochemically-based mechanisms of toxicity, such as mutagenicity and carcinogenicity.
    • Familiarity with open source QSAR platforms and graphical user interface (GUI) development.
    • Familiarity with broad classes of agricultural chemicals.
    • Experience and practical knowledge of global regulations and regulatory processes for human health risk assessments for agrochemicals using QSAR softwares.
    • Practical GLP laboratory experience and detailed working knowledge of study design and data requirements in the areas of QSAR predictions.
    • Experience of supporting biologicals would also be an advantage.
    • Registration knowledge for biocides, pharmaceutical, or specialty chemicals
    • Experience communicating with non-science, business customers and global Registrations Managers and meeting their expectations

    EEO Statement

    FMC employees enjoy competitive compensation, a menu of work/life benefits and opportunities to continue developing their skills and building their career. FMC is an Equal Opportunity Employer and makes employment decisions without regard to race, gender, disability or protected veteran status. FMC supports a drug-free workplace. 

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